Adrenal Leukodystrophy and Women

Dr Shoji Tsuji. Tokyo University Hospital. The International University of Health and Welfare Genomic Medicine Research Institute. Aadrenal leukodystrophy originally developed in boys of school age, and is called the white matter  Inflammatory demyelination in the area where nerve fibers are gathered and pass) is a disease in which the nervous system covering the nerve…

Nonpharmacologic Approaches to Spasticity Management

Spasticity, defined as a velocity-dependent increase in muscle tone caused by the increased excitability of the muscle stretch reflex, is a challenging symptom that frequently accompanies severe neurological conditions including stroke, multiple sclerosis (MS), cerebral palsy (CP), and spinal cord injury.1 The mechanisms of spasticity are complex, involving an inhibitory/excitatory disruption to the spinal network…

The Role of Spasticity in Functional Neurorehabilitation- Part I: The Pathophysiology of Spasticity, the Relationship with the Neuroplasticity, Spinal Shock and Clinical Signs

Abstract The symptom/clinical sign of spasticity is extremely important in functional neurorehabilitation, since it reduces the functional independence both in the quadruped animal as in the human biped. This clinical sign/symptom manifests itself alongside with pain, muscle weakness, impaired coordination and poor motor planning, leading to a spastic movement disorder. To perform a correct FNR…

Clinical management of spasticity

Physical and pharmacological treatments can reduce pain and discomfort without compromising function Spasticity is a common symptom seen in many neurological conditions, notably head injury, spinal cord injury, stroke, cerebral palsy, and multiple sclerosis. It is also the dominant feature in several rarer conditions such as tropical and hereditary spastic paraparesis. The fact that it…

Ipsen has announced the UK’s Medicine and Healthcare Products Regulatory Agency approved Dysport® for the treatment of spasticity of upper limbs in children with cerebral palsy.

Cerebral palsy: first European drug approval in upper limb spasticity for a decade By Shakera Halim – 7th January 2020 This approval – which is the first of its kind in Europe for over a decade – follows a previous approval to treat patients of the same age with lower limb spasticity, making Dysport® the first botulinum toxin to be…

Spasticity: two potential therapeutic avenues

Date: March 16, 2016 Source: CNRS Summary: Following spinal cord injury, most patients experience an exaggeration of muscle tone called spasticity, which frequently leads to physical disability. A team has just identified one of the molecular mechanisms responsible for this phenomenon. It has also proposed two therapeutic solutions that have proved conclusive in animals, one…

New Way to Administer Spasticity-Preventing Drug Reaches Clinical Trials

March 15, 2019 by Kevin Coss For people who have medical issues like cerebral palsy, multiple sclerosis, and brain and spinal cord injuries, spasticity and involuntary muscle contractions are common. An existing muscle relaxant called baclofen helps to reduce these spams if taken routinely—but sometimes therapy is abruptly interrupted, which can result in serious adverse…

Effect of radial shock wave therapy on pain and muscle hypertonia: a double-blind study in patients with multiple sclerosis.

Marinelli L1, Mori L2, Solaro C3, Uccelli A2, Pelosin E2, Currà A4, Molfetta L2, Abbruzzese G2, Trompetto C2. Author information Abstract BACKGROUND: Radial shock wave therapy (RSWT) has been extensively used in rehabilitative medicine to treat pain, and more recently muscle hypertonia, in patients with cerebral palsy and stroke. OBJECTIVES: To assess the long-term effects…

A Review of Spasticity Treatments: Pharmacological and Interventional Approaches

Eric Chang,1,*†Nilasha Ghosh,2,†Daniel Yanni,3Sujin Lee,1Daniela Alexandru,3 and Tahseen Mozaffar4Author informationCopyright and License informationDisclaimerThe publisher’s final edited version of this article is available at Crit Rev Phys Rehabil MedSee other articles in PMC that cite the published article.Go to: Abstract Spasticity is a velocity-dependent increase in muscle tone and uncontrolled, repetitive, involuntary contractions of skeletal muscles.…

Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: A paradigm for multifactorial neurodegenerative diseases?

Abstract X-linked adrenoleukodystrophy (X-ALD) is an inherited neurodegenerative disorder expressed as four disease variants characterized by adrenal insufficiency and graded damage in the nervous system. X-ALD is caused by a loss of function of the peroxisomal ABCD1 fatty-acid transporter, resulting in the accumulation of very long chain fatty acids (VLCFA) in the organs and plasma,…