The Role of Spasticity in Functional Neurorehabilitation- Part I: The Pathophysiology of Spasticity, the Relationship with the Neuroplasticity, Spinal Shock and Clinical Signs

Abstract The symptom/clinical sign of spasticity is extremely important in functional neurorehabilitation, since it reduces the functional independence both in the quadruped animal as in the human biped. This clinical sign/symptom manifests itself alongside with pain, muscle weakness, impaired coordination and poor motor planning, leading to a spastic movement disorder. To perform a correct FNR…

Spasticity: two potential therapeutic avenues

Date: March 16, 2016 Source: CNRS Summary: Following spinal cord injury, most patients experience an exaggeration of muscle tone called spasticity, which frequently leads to physical disability. A team has just identified one of the molecular mechanisms responsible for this phenomenon. It has also proposed two therapeutic solutions that have proved conclusive in animals, one…

New Way to Administer Spasticity-Preventing Drug Reaches Clinical Trials

March 15, 2019 by Kevin Coss For people who have medical issues like cerebral palsy, multiple sclerosis, and brain and spinal cord injuries, spasticity and involuntary muscle contractions are common. An existing muscle relaxant called baclofen helps to reduce these spams if taken routinely—but sometimes therapy is abruptly interrupted, which can result in serious adverse…