The Role of NAC in Amyloidogenesis in Alzheimer’s Disease

In 1993, Saitoh and colleagues identified the non-Aβ component of Alzheimer’s disease (AD), amyloid (NAC), as an important element of amyloid-enriched fractions in AD brains. 1 NAC is a 35-amino acid (aa) fragment derived from its 140-aa precursor, α-synuclein, which is now recognized to play a major role in Lewy body disease (LBD) pathogenesis. 2…

Neuron differentiation and neuritogenesis stimulated by N-acetylcysteine (NAC).

Abstract AIM: To investigate the effect of N-acetylcysteine (NAC), a potent antioxidant, on neuron differentiation of cultured mouse embryonic stem cells (ESCs) induced by retinoic acid (RA) in vitro. Superior cervical ganglion (SCG) neurons were used to study the effect of NAC on neuritogenesis. METHODS: Immunoblotting was performed to detect the expression of microtubule-associated protein…

N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities

Abstract Background There is an expanding field of research investigating the benefits of medicines with multiple mechanisms of action across neurological disorders. N-acetylcysteine (NAC), widely known as an antidote to acetaminophen overdose, is now emerging as treatment of vascular and nonvascular neurological disorders. NAC as a precursor to the antioxidant glutathione modulates glutamatergic, neurotrophic, and…

N-ACETYLCYSTEINE REDUCES DISEASE ACTIVITY BY BLOCKING MTOR IN T CELLS OF LUPUS PATIENTS

Associated Data Supplementary MaterialsGo to: Abstract Background Systemic lupus erythematosus (SLE) patients exhibit T-cell dysfunction which can be regulated through the mitochondrial transmembrane potential (Δψm) and mammalian target of rapamycin (mTOR) by glutathione. Therefore, the safety, tolerance, and efficacy of glutathione-precursor N-acetylcysteine (NAC) were examined in this randomized double-blind placebo-controlled study. Methods 36 SLE patients…

Getting a Knack for NAC

Abstract N-acetyl-cysteine, N-acetylcysteine, N-acetyl cysteine, and N-acetyl-L-cysteine are all designations for the same compound, which is abbreviated as NAC. NAC is a precursor to the amino acid cysteine, which ultimately plays two key metabolic roles. Through its metabolic contribution to glutathione production, cysteine participates in the general antioxidant activities of the body. Through its role…

A Review on Various Uses of N-Acetyl Cysteine

Abstract N-acetyl cysteine (NAC), as a nutritional supplement, is a greatly applied antioxidant in vivo and in vitro. NAC is a precursor of L-cysteine that results in glutathione elevation biosynthesis. It acts directly as a scavenger of free radicals, especially oxygen radicals. NAC is a powerful antioxidant. It is also recommended as a potential treatment…

Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases

Abstract N-acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific interest for decades due to its important medical applications. It also represents a nutritional supplement in the human diet. NAC is a glutathione precursor and shows antioxidant and anti-inflammatory activities. In addition to the uses quoted in the literature, NAC may be considered…

N-acetyl-L-cysteine improves outcome of advanced cerebral adrenoleukodystrophy

Abstract Hematopoietic stem cell transplantation as a treatment for childhood cerebral adrenoleukodystrophy (ALD) has historically only been successful in early disease. As ALD is associated with oxidative damage, we reasoned that adjunctive therapy with an antioxidant agent, N-acetyl-L-cysteine (NAC), may provide protection from rapid neurologic decline in boys with advanced cerebral disease. We report three…