Antioxidants Halt Axonal Degeneration in a Mouse Model of X-Adrenoleukodystrophy

Objective: Axonal degeneration is a main contributor to disability in progressive neurodegenerative diseases in which oxidative stress is often identified as a pathogenic factor. We aim to demonstrate that antioxidants are able to improve axonal degeneration and locomotor deficits in a mouse model of X-adrenoleukodystrophy (X-ALD). Methods: X-ALD is a lethal disease caused by loss…