Combo of Antioxidants a Potential Therapy for Adrenomyeloneuropathy, Trial Suggests

Targeting oxidative stress with antioxidants holds promise to improve symptoms of adrenomyeloneuropathy (AMN), a pilot Phase 2 study suggests. The results show that treatment with a combo of antioxidants decreases inflammation and enhances patients’ walking capacity. The study, “Biomarker identification, Safety and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot study,” was published…

Antioxidants Halt Axonal Degeneration in a Mouse Model of X-Adrenoleukodystrophy

Objective: Axonal degeneration is a main contributor to disability in progressive neurodegenerative diseases in which oxidative stress is often identified as a pathogenic factor. We aim to demonstrate that antioxidants are able to improve axonal degeneration and locomotor deficits in a mouse model of X-adrenoleukodystrophy (X-ALD). Methods: X-ALD is a lethal disease caused by loss…